Callizot N., Andriambeloson E., Glass J., Revel M., Ferro P., the most beautiful ukrainian girl., Vitte P.-A., Dreano M. 2008. Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity. Cancer Chemother. Pharmacol. 62, 995-1007

Andriambeloson E.,Baillet-Mignard C., Vitte PA., Garotta G., Dreano M., Callizot N. 2006. Interleukin-6 prevents the development of experimental diabetes-related neuropathy. Neuropathology 26, 32-42

Pizzi M., Sarnico I., Boroni F., Benarese M., Dreano M., Garotta G., Valerio A., Spano PF. 2004. Interleukin-6 (IL-6) and IL6 receptor/IL6 fusion protein prevent neuron and oligodendrocyte degeneration in organotypic hippocampal slices exposed to excitotoxic injury. Mol. Cell. Neurosci. 24, 301-311

Valerio A., Ferrario M., Dreano M., Garotta G., Spano P., Pizzi M. 2002. Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cells. Mol. Cell. Neurosi. 21, 602-15

Bensadoun JC., de Almeida LP., Dreano M., Aebischer P., Deglon N. 2001. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington’s syndrome. Eur. J. Neurosci. 14, 1753-1761



Jordheim LP., Plesa A., Dreano M., Cros-Perrial E., Keime C., Herveau S., Demangel D., Vendrell J.A., Dumontet C.  2011. Sensitivity and gene expression proWle of fresh human acute myeloid leukemia cells exposed ex vivo to AS602868. Cancer Chemother. Pharmacol. 68, 97–105
Lounnas N., Frelin C., Gonthier N., Colosetti P., Sirvent A., Cassuto J.-P., Berthier F., Sirvent N., Rousselot P., Dreano M., Peyron J.-F., Imbert V. 2009. NF- kB inhibition triggers death of imatinib-sensitive and imatinib-resistant chronic myeloid leukemia cells including T315I Bcr-Abl mutants. Int. J. Cancer 125, 308-317
Griessinger E., Hélias V., Cuburu N., Imbert V., Frelin C., Dageville C., Hummelsberger M., Sirvent N., Dreano M., Peyron J.F. 2008. Pre-clinical targeting of NF-kB and Flt3 pathways in AML cells. Leukemia 22, 1466-1469
Lagadec P., Grissinger E.; Nawrot M.-P.; Fenouille N., Colosetti P., Imbert V.; Mari M.; Hofman P.; Czerucka D.; Rousseau P.; Berard E; Dreano M.; Peyron J.-F. 2008. Pharmacological targeting of NF-kB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells. Br. J. Cancer 98, 335-344
Sors A., Jean-Louis F., Bégué E., Parmentier L., Dubertret L., Dreano M., Courtois G., H. Bachelez, L. Michel. 2008. Inhibition of IKK02 in cutaneous T cell lymphoma dowregulates NF-kappaB constitutive activation, induces cell death and potentiates the apoptotic response to antineoplastic chemotherapeutic drugs. Clin. Cancer Res. 14, 901-911
Griessinger E., Frelin C., Cuburu N., Imbert V., Dageville C., Hummelsberger M., Sirvent N., Dreano M., Peyron JF. 2008. Preclinical targeting of NF-kappaB and FLT3 pathways in AML cells. Leukemia 22, 1466-1469
Romagnoli M., Desplanques G., Maiga S., Legouill S., Dreano M., Bataille R., Barillé-Nion S. 2007. Inhibition of the canonical NF-kB pathway blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL. Clinical Cancer Res. 13, 1-9
Griessinger E., Imbert V., Dubreuil P., Dreano M., Peyron J.-F. 2007. Dual inhibition of NFKB and FLT3 by a small molecule inhibitor of IKK2 to target AML cells. Leukemia 21, 877–885
Jourdan M., Moreaux J., De Vos J., Hose D.,  Mahtouk K., Abouladze M., Robert N.,  Baudard M., Reme T., Romanelli A., Rossi J.-F., Goldschmidt H., Dreano M., Klein B. 2007 Targeting NFkB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth. Br. J. Haematol. 138, 160-168
Frelin C., Imbert V., Griessinger E., Peyron AC., Rochet N., Philip P., Dageville C., Sirvent A., Dreano M., Sirvent N., Peyron JF. 2005. Targeting NF-kB activation via pharmacological inhibition of IKK2 induced apoptosis of human Acute Myeloid Leukemia cells. Blood 105, 804-811
Frelin C., Imbert V., Griessinger E., Loubat A., Dreano M., Peyron JF. 2003. AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF- in Jurkat leukemic cells. Oncogene 22, 8187-8194
Prigent P., El Mir S., Dreano M., Triebel F. 1999. Lymphocyte activation gene-3 induces tumor regression and antitumor immune responses. Eur. J. Immunol. 29, 3867-3876
Huard B., Mastrangeli R., Prigent P., Bruniquel D., Donini S., El-Tayar N., Maigret B., Dreano M. Triebel F. 1997. Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.  Proc. Nat. Acad. Sci. USA. 94, 5744-5749



Sulpice T., Prunet-Marcassus B., Molveaux C.,Cani P., Vitte P.A., Graber P., Dreano M., Burcelin R. 2009. An adiponectin-like molecule with antidiabetic properties. Endocrinol. 150, 4493-4501

Tiberio G.A.M., Tiberio L., Benetti A., Cervi E., Montani M., Dreano M., Garotta G., Cerea K., Steimberg N., Pandolfo G., Ferrari-Bravo A., Mazzoleni G., Giulini S.M., Schiaffonati L. 2008. IL-6 promotes compensatory liver regeneration in cirrhotic rat after hepatectomy. Cytokine 42, 372-378

Beraza N., Malato Y., Vander Borght S, Liedtke C., Wasmuth H.E., Dreano M., de Vos R., Roskams T., Trautwein C. 2008. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic-steatohepatitis. Gut 57, 655-663

Tiberio L., Tiberio GAM., Bardella L., Cervi E., Cerea K., Dreano M., Garotta G., Fra A., Montani N., Ferrari-Bravo A., Callea F., Grigolato P., Giulini SM., Schiaffonatti L. 2006. Mechanism of interleukin-6 protection against ischemia-reperfusion injury in rat liver. Cytokine 34, 131-142

Comini L., Pasini E., Bachetti T., Dreano M., Garotta G., Ferrari R. 2005. Acute Haemodynamic Effects of IL-6 Treatment In Vivo: Involvement of Vagus Nerve in NO-Mediated Negative Inotropism. Cytokine 30, 236-242



Xu G., Lo Y.C., Li Q., Napoletano G., Wu X., Jiang X., Dreano M., Karin M., Wu H. 2011. Crystal structure of inhibitor of kB kinase beta. Nature 472, 325-330

Jiang X., Dreano M., Buckler DR., Cheng S., Ythier A., Wu H., Hendrickson WA., El Tayar N. 1995 Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 3, 1341-1353.


Caposio P., Dreano M., Garotta G., Gribaudo G., Landolfo S. 2004. Human cytomegalovirus activates cellular IKK2 activity and requires the enzyme for productive replication.  J. Virol. 78, 3190-3195

Heckmann A., Waltzinger C., Jolicoeur P., Dreano M., Kosco-Vilbois M., Sagot Y. 2004. NK-kB inhibitor alleviates kidney and wasting diseases in a model of human AIDS. Am. J. Pathol.164, 1253-1262.

Dreano M., Bellocq C., Fichot O., van der Werf S., Girard M. 1985. Genetic variations in the Mahoney strain of poliovirus type 1. Ann. Virol. 136, 101-114

van der Werf S., Dreano M., Bruneau P., Kopecka H., Girard M. 1983. Expression of poliovirus capsid polypeptide VP1 in Escherichia coli. Gene. 23, 85-93.

Kopecka H., van der Werf S., Bregegere F., Kitamura N., Dreano M., Rothberg PG., Wimmer E., Kourilsky P., Girard M. 1981. Restriction map of poliovirus type 2 cDNA. Devel. Biol. 50, 301-309.

Agut H., Matsukura T., Bellocq C., Dreano M., Nicolas JC., Girard M. 1981. Isolation and preliminary characterization of temperature sensitive mutants of poliovirus type 1. Ann. Virol. 132, 445-460

Dreano M., Bellocq C., Fichot O., van der Werf S., Girard M. 1985. Genetic variations in the Mahoney strain of poliovirus type 1. Ann. Virol. 136, 101-114



L’Hote P., Alouani S., Marq JB., Montandon F., Chessebeuf-Padieu M., Dreano M. 1993. Concomitant cellular expression of heat shock regulated genes of hepatitis B virus surface antigen and of human growth hormone by a NIH-3T3 cell line. Cell Biol. Toxicol. 9, 319-332.

Montandon F., Cao H., Dreano M., Padieu P. 1992. [Immortalization of cultured cells by the Ha-rasEJ oncogene and expression of a gene of biogenetic value]. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 186, 501-506

Alouani S., L’Hote P., Marq JB., Houdebine LM., Montandon F., Chessebeuf-Padieu M., Dreano M. 1992. Expression of heat shock-regulated human growth hormone genes containing or lacking introns by NIH-3T3 and Wish cell lines. Cell Biol. Toxicol. 8, 139-156

Bearzotti M., Perrot E., Michard-Vanhee C., Jolivet G., Attal J., Theron MC., Puissant C., Dreano M., Kopchick JJ., Powell R., Gannon F., Houdebine LM., Chourrout D. 1992. Gene expression following transfection of fish cells. J. Biotechnol. 26, 315-325

Fischbach M., Cao HW., Diez Ibanez M., Tsaconas C., Alouani S., Montandon F., El Baraka M., Padieu P., Dreano M., Chessebeuf-Padieu M. 1991. Maintenance of liver function in long term culture of hepatocytes following in vitro or in vivo Ha-rasEJ transfection. Cell Biol. Toxicol. 7, 327-345

Dreano M., Marq JB., Bromley P. 1988. Antibody formation against heat-induced gene products expressed in animals. Bio/Technol. 6, 1340-1343

Dreano M., Fischbach M., Montandon F., Salina C., Padieu P., Bromley P. 1988. Production of secretable proteins using the passage in vivop as tumours of cells carrying heat-inducible constructs. Bio/Technol. 6, 953-958

Dreano M., Fouillet X., Brochot J., Vallet JM., Michel ML., Rungger D., Bromley P. 1987. Heat-regulated expression of the hepatitis B virus surface antigen in the human Wish cell line. Virus Res. 8, 43-59

Amin J., Mestril R., Schiller P., Dreano M., Voellmy R. 1987. Organization of the Drosophila melanogaster hsp70 heat shock regulation unit. Mol. Cell. Biol. 7, 1055-1062.

Dreano M., Brochot J., Myers A., Cheng-Meyer C., Rungger D., Voellmy R., Bromley P. 1986. High-level, heat-regulated synthesis of proteins in eukaryotic cells. Gene. 49, 1-8.